Validation of the flash-evoked response from fetal MEG
Author(s) / Creator(s)
McCubbing, J.
Murphy, P.
Eswaran, H
Preissl, H.
Yee, T.
Robinson, S. E.
Vrba, J.
Abstract / Description
Flash-evoked responses can be recorded from the fetus in utero. However, a standard analysis approach based on orthogonal projection (OP) to attenuate maternal and fetal cardiac signals leads to a spatial redistribution of the signal. This effect prevents the correlation of source location with a known fetal head location in some cases and the signal-to-noise ratio (SNR) is sometimes limited such that the response latency is difficult to determine. We used a modified beamformer model search analysis to avoid the redistribution shortcoming and to improve the SNR. We included a statistical test for residual interference in the average and quantified significance of the evoked response with a bootstrap method. Selected source locations compared favorably to fetal head locations estimated from ultrasound exams. The evoked response time course was found to have a significant post-trigger peak with a latency between about 180 and 770 ms in more than 90% of the subject measurements. These results confirm that the combined application of a beamformer model search and bootstrap significance test provides a validation of the flash-evoked response observed in OP processed fetal MEG channels.
Keyword(s)
Fetus Magnetoencephalographie Visuell evoziertes Potenzial Test Validität Visuell evozierte Potentiale Elektrookulographie Visuelle Stimulation Magnetoencephalographie Testreliabilität fetus MEG Flash-evoked responses validation spatial redistribution signal-to-noise ratioPersistent Identifier
Date of first publication
2007
Publication status
unknown
Review status
unknown
Citation
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Preissl_pmb_2007_7_19_005.pdfAdobe PDF - 384.33KBMD5: fb7fb606c12f4a2d6fb3d1a1797875ad
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There are no other versions of this object.
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Author(s) / Creator(s)McCubbing, J.
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Author(s) / Creator(s)Murphy, P.
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Author(s) / Creator(s)Eswaran, H
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Author(s) / Creator(s)Preissl, H.
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Author(s) / Creator(s)Yee, T.
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Author(s) / Creator(s)Robinson, S. E.
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Author(s) / Creator(s)Vrba, J.
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PsychArchives acquisition timestamp2022-11-22T06:49:54Z
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Made available on2008-08-08
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Made available on2015-12-01T10:32:16Z
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Made available on2022-11-22T06:49:54Z
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Date of first publication2007
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Abstract / DescriptionFlash-evoked responses can be recorded from the fetus in utero. However, a standard analysis approach based on orthogonal projection (OP) to attenuate maternal and fetal cardiac signals leads to a spatial redistribution of the signal. This effect prevents the correlation of source location with a known fetal head location in some cases and the signal-to-noise ratio (SNR) is sometimes limited such that the response latency is difficult to determine. We used a modified beamformer model search analysis to avoid the redistribution shortcoming and to improve the SNR. We included a statistical test for residual interference in the average and quantified significance of the evoked response with a bootstrap method. Selected source locations compared favorably to fetal head locations estimated from ultrasound exams. The evoked response time course was found to have a significant post-trigger peak with a latency between about 180 and 770 ms in more than 90% of the subject measurements. These results confirm that the combined application of a beamformer model search and bootstrap significance test provides a validation of the flash-evoked response observed in OP processed fetal MEG channels.en
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Publication statusunknown
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Review statusunknown
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ISSN0031-9155
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Persistent Identifierhttps://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:291-psydok-21518
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Persistent Identifierhttps://hdl.handle.net/20.500.11780/1150
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.11315
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Language of contenteng
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Is part ofPhysics in Medicine and Biology, 52 5803-5813
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Keyword(s)Fetusde
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Keyword(s)Magnetoencephalographiede
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Keyword(s)Visuell evoziertes Potenzialde
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Keyword(s)Testde
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Keyword(s)Validitätde
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Keyword(s)Visuell evozierte Potentialede
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Keyword(s)Elektrookulographiede
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Keyword(s)Visuelle Stimulationde
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Keyword(s)Magnetoencephalographiede
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Keyword(s)Testreliabilitätde
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Keyword(s)fetusen
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Keyword(s)MEGen
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Keyword(s)Flash-evoked responsesen
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Keyword(s)validationen
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Keyword(s)spatial redistributionen
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Keyword(s)signal-to-noise ratioen
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Dewey Decimal Classification number(s)150
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TitleValidation of the flash-evoked response from fetal MEGen
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DRO typearticle
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Visible tag(s)PsyDok