The effect of natural habituation on coagulation responses to acute mental stress and recovery in men
Author(s) / Creator(s)
von Känel, Roland
Preckel, Daniel
Zgraggen, Lilian
Mischler, Katharina
Kudielka, Brigitte M.
Haeberli, André
Fischer, Joachim E.
Abstract / Description
Blood coagulation activation might be mechanism linking acute mental stress with coronary events. We investigate the natural habituation of coagulation responses and recovery to short-term mental stress. Three times with one-week intervals, 24 men (mean age 47 +/- 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery) Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Wilebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (ps ≤ 0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p=0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (ps ≤ 0.041). Before catheter insertion, systolic blood pressure (p=0.001) and heart rate (p=0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p=0.007) and the cortisol recovery from stress (p=0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Syphathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.
Keyword(s)
Blutgerinnung Herzkrankheit Stress Gewöhnung WiederherstellungPersistent Identifier
Date of first publication
2004
Publication status
unknown
Review status
unknown
Citation
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von_Kaenel_et_al_2004_Thromb_Haemost.pdfAdobe PDF - 644.75KBMD5: 1df9f7f8edde849c5ca32f059619ad2e
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Author(s) / Creator(s)von Känel, Roland
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Author(s) / Creator(s)Preckel, Daniel
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Author(s) / Creator(s)Zgraggen, Lilian
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Author(s) / Creator(s)Mischler, Katharina
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Author(s) / Creator(s)Kudielka, Brigitte M.
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Author(s) / Creator(s)Haeberli, André
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Author(s) / Creator(s)Fischer, Joachim E.
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PsychArchives acquisition timestamp2022-11-22T06:49:46Z
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Made available on2008-05-15
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Made available on2015-12-01T10:30:33Z
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Made available on2022-11-22T06:49:46Z
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Date of first publication2004
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Abstract / DescriptionBlood coagulation activation might be mechanism linking acute mental stress with coronary events. We investigate the natural habituation of coagulation responses and recovery to short-term mental stress. Three times with one-week intervals, 24 men (mean age 47 +/- 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery) Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Wilebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (ps ≤ 0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p=0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (ps ≤ 0.041). Before catheter insertion, systolic blood pressure (p=0.001) and heart rate (p=0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p=0.007) and the cortisol recovery from stress (p=0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Syphathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.en
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Publication statusunknown
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Review statusunknown
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ISSN0340-6245
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Persistent Identifierhttps://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:291-psydok-15830
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Persistent Identifierhttps://hdl.handle.net/20.500.11780/467
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.11288
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Language of contenteng
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Is part ofThrombosis and Haemostasis, 92: 1327-1335.
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Keyword(s)Blutgerinnungde
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Keyword(s)Herzkrankheitde
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Keyword(s)Stressde
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Keyword(s)Gewöhnungde
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Keyword(s)Wiederherstellungde
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Keyword(s)Blutgerinnungde
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Keyword(s)Herzkrankheitde
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Keyword(s)Stressde
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Keyword(s)Gewöhnungde
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Keyword(s)Wiederherstellungde
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Keyword(s)cardiovascular diseaseen
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Keyword(s)stressen
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Keyword(s)rehabilitationen
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Dewey Decimal Classification number(s)150
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TitleThe effect of natural habituation on coagulation responses to acute mental stress and recovery in menen
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DRO typearticle
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Visible tag(s)PsyDok