Article

The effect of natural habituation on coagulation responses to acute mental stress and recovery in men

Author(s) / Creator(s)

von Känel, Roland
Preckel, Daniel
Zgraggen, Lilian
Mischler, Katharina
Kudielka, Brigitte M.
Haeberli, André
Fischer, Joachim E.

Abstract / Description

Blood coagulation activation might be mechanism linking acute mental stress with coronary events. We investigate the natural habituation of coagulation responses and recovery to short-term mental stress. Three times with one-week intervals, 24 men (mean age 47 +/- 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery) Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Wilebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (ps ≤ 0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p=0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (ps ≤ 0.041). Before catheter insertion, systolic blood pressure (p=0.001) and heart rate (p=0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p=0.007) and the cortisol recovery from stress (p=0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Syphathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.

Keyword(s)

Blutgerinnung Herzkrankheit Stress Gewöhnung Wiederherstellung Blutgerinnung Herzkrankheit Stress Gewöhnung Wiederherstellung cardiovascular disease stress rehabilitation

Persistent Identifier

Date of first publication

2004

Publication status

unknown

Review status

unknown

Citation

  • Author(s) / Creator(s)
    von Känel, Roland
  • Author(s) / Creator(s)
    Preckel, Daniel
  • Author(s) / Creator(s)
    Zgraggen, Lilian
  • Author(s) / Creator(s)
    Mischler, Katharina
  • Author(s) / Creator(s)
    Kudielka, Brigitte M.
  • Author(s) / Creator(s)
    Haeberli, André
  • Author(s) / Creator(s)
    Fischer, Joachim E.
  • PsychArchives acquisition timestamp
    2022-11-22T06:49:46Z
  • Made available on
    2008-05-15
  • Made available on
    2015-12-01T10:30:33Z
  • Made available on
    2022-11-22T06:49:46Z
  • Date of first publication
    2004
  • Abstract / Description
    Blood coagulation activation might be mechanism linking acute mental stress with coronary events. We investigate the natural habituation of coagulation responses and recovery to short-term mental stress. Three times with one-week intervals, 24 men (mean age 47 +/- 7 years) underwent the same 13-min stressor (preparation, job interview, mental arithmetic). During each visit venous blood was obtained four times (baseline, immediately post-stress, 45 min of recovery, 105 min of recovery) Eight blood coagulation parameters were measured at weeks one and three. Acute stress provoked increases in von Wilebrand factor antigen, fibrinogen, clotting factor FVII activity (FVII:C), FVIII:C, FXII:C (ps ≤ 0.019), and D-dimer (N.S.). All coagulation parameters experienced full recovery except FVIII:C (p=0.022). Stress did not significantly affect activated partial thromboplastin time and prothrombin time. At all time points FVIII:C and FXII:C levels were significantly higher at week one compared to week three (ps ≤ 0.041). Before catheter insertion, systolic blood pressure (p=0.001) and heart rate (p=0.026) were relatively higher at week one. Unlike the magnitude of systolic blood pressure response to stress (p=0.007) and the cortisol recovery from stress (p=0.002), the magnitude of all coagulation responses to stress and the recovery from stress were similar in week one and week three. Syphathetic activation with anticipatory stress best explained increased baseline activity in FVIII and FXII at week one. An incapacity of the coagulation system to adapt to stress repeats is perhaps a consequence of evolution, but might also contribute to increased coronary risk in some individuals, particularly in those with cardiovascular diseases.
    en
  • Publication status
    unknown
  • Review status
    unknown
  • ISSN
    0340-6245
  • Persistent Identifier
    https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bsz:291-psydok-15830
  • Persistent Identifier
    https://hdl.handle.net/20.500.11780/467
  • Persistent Identifier
    https://doi.org/10.23668/psycharchives.11288
  • Language of content
    eng
  • Is part of
    Thrombosis and Haemostasis, 92: 1327-1335.
  • Keyword(s)
    Blutgerinnung
    de
  • Keyword(s)
    Herzkrankheit
    de
  • Keyword(s)
    Stress
    de
  • Keyword(s)
    Gewöhnung
    de
  • Keyword(s)
    Wiederherstellung
    de
  • Keyword(s)
    Blutgerinnung
    de
  • Keyword(s)
    Herzkrankheit
    de
  • Keyword(s)
    Stress
    de
  • Keyword(s)
    Gewöhnung
    de
  • Keyword(s)
    Wiederherstellung
    de
  • Keyword(s)
    cardiovascular disease
    en
  • Keyword(s)
    stress
    en
  • Keyword(s)
    rehabilitation
    en
  • Dewey Decimal Classification number(s)
    150
  • Title
    The effect of natural habituation on coagulation responses to acute mental stress and recovery in men
    en
  • DRO type
    article
  • Visible tag(s)
    PsyDok